I cannot provide a specific recommendation about the effectiveness of Pranicure, mostly because it seems to be a proprietary formulation and the list of ingredients is not available on line as best I can tell.
However, generally speaking, it is best to approach anal itching with the help of your regular doctors
">primary care doctor or with a gastroenterology
specialist. I say this because there are many different causes of anal itching and the most effective treatments are targeted at an identifiable cause.
For example, if the itching is from rectal hemorrhoids, then using a cream known to be effective for hemorrhoids would be the best approach. On the other hand, if the condition is due to a skin condition, such as a contact allergy, then identifying the offending substance that is causing the allergy is the best step.
I do understand that you've tried to get help from several doctors in the past without much luck. However, my recommendation would still be to try again, perhaps with a doctor that you trust or know well. They should be able to provide you with some advice. If you have on hand some of the Pranicure cream, they can also look at that to see if the list of ingredients is available and makes sense.