I would recommend that you seek evaluation by your doctor
or a healthcare professional for your symptoms so that you may undergo the appropriate testing if necessary, determine a diagnosis and develop a management plan for your symptoms. A sensation of an empty stomach can have multiple causes, some benign and others more severe. Appetite is often associated with the sensation of an empty stomach, and hunger is stimulated by a neurohormone called ghrelin. This compound is released by the stomach and signals to the brain. Increased appetite or a sense of having an empty stomach is often associated with changes in metabolism, for example, as often seen with starting a new workout regimen. However, an empty stomach sensation be a symptom of a more serious problem such as damage to the stomach and proximal intestine. Patients who have a history of reflux or GERD, may develop symptoms of indigestion that may feel like stomach irritation. Patients with a history of peptic ulcer
disease (PUD) may develop ulcers of the stomach and duodenum (part of the small intestine) that can provide a sensation of pain in the epigastric region. Another disease process that causes stomach irritation is gastritis, which often feels worse after eating. Finally, certain malignancies such as gastric or pancreatic cancer can sometimes be associated with epigastric pain, and are also frequently associated with other symptoms such as unintentional weight loss
. Please see your doctor so that you can be appropriately evaluated for your symptoms and receive treatment if necessary.