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"What's the minimum amount of time I have to wait between these meds?"

ZocdocAnswersWhat's the minimum amount of time I have to wait between these meds?


im 19,have spina bifida (but no paralysis) i take lyrica 25mg 3x day,morphine sulfate extended release 30mg 2x day,flexeril 10mg 1-2x day,baclofen 10mg 3x day,and amitriptyline 25mg 1x day (at bedtime) .ones im afraid of is the morphine and flexeril and amitriptyline becuz i read prescription papers that came with meds when i got em refilled and it said additional care and monitoring of condition is needed if you take these meds and really only things i take in that list is flexeril and baclofen but am also kinda worried the amitriptyline alittle too.thanks have a great nite!


Thanks for your question. It is always good to be concerned about polypharmacy when you are taking multiple medications. This is especially true when you are taking multiple medications that work on the same part of your body or are metabolized by the same system (eg, your kidneys, which help to remove many of the medications that we take on a regular basis). Unfortunately, there are many conditions when it is important or necessary to take multiple medications to manage symptoms. In these cases, it is good to work with your doctor to make sure that your medications are not building on each other or cross reacting. Many people will require different doses of medication based on a number of personal factors. In addition to the fact that some people have kidneys, livers, and other metabolic systems that work at different rates, there is also the fact some people have built up tolerances to some medications. For example, in your case, 30mg of morphine would be quite a bit for some people, and not quite enough for others. In short, in order to fully answer your question, you need to speak with your doctor about your symptoms and results. Again, please speak with your doctor.

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