Thank you for your question. There are many things that can affect sex hormone binding globulin, some of which can make the levels increase and others that can make the levels decrease. It is important to speak with your doctor
about your concern. The fact that you have been hypothyroid (had a non or poorly functioning thyroid gland) can explain part of the fact that your levels of this hormone are off, but there may be other things affecting this as well. Oral contraceptives are another common factor that can affect these levels, but there really are myriad other explanations. In this case, it is important to understand how this hormone is affecting the rest of your symptoms and your overall well being, ie, is this a sign of other things going on, or is it somehow at the bottom of the problems? Your doctor will know best how to direct you from here, and will likely have some further testing that has already been completed or that will be completed in the future and can help explain the relative value of this test. Remember that a certain percentage of tests will be abnormal, and yet not be abnormal for you, and so you have to understand this value in a broader context. Please speak with your doctor.