Medical questions & health advice by board certified doctors

"is 3750mg acetaminophen over 6 days alright for my liver?"

ZocdocAnswersis 3750mg acetaminophen over 6 days alright for my liver?


I've read everywhere that the max safe dosage for acetaminophen (what's in tylenol and vicodin and lots of other painkillers) is about 4000mg a day. I've taken 3750 mg daily over like 3 days and will continue for about 3 more days. Is the threshold lower for the max dosage if I take it enough days in a row? Thanks


Thank you for your questions. I would recommend speaking with your primary care physician to ensure that the dose of tylenol that you are taking is safe when taking into consideration your other medical problems and medications, if any. You are correct that many regard the maximum recommended daily dose of acetaminophen for adults to be 4,000mg. For the number of days that you are planning to take nearly that dose, you are unlikely to have problems with liver toxicity, although there are several caveats. Overdoses and toxicity often occur when individuals mix Tylenol with combination analgesic medications that also contain acetaminophen (Vicodin or Percocet, for example). Because of this, many practitioners (as well as the makers of Tylenol) have changed their recommended maximum daily dose to 3,000mg rather than 4,000mg. It is important to always read the dosing instructions and labels for all pain medications that you are taking. Additionally, there are several factors that may increase one's risk of liver toxicity with acetaminophen use. These include chronic alcohol ingestion, malnutrition, and advanced age. If you have liver cirrhosis, many physicians would recommend a maximum daily dose of 2,000mg. Finally, if you are concerned about excessive usage of acetaminophen, many patients are able to use both Tylenol and NSAID medications (such as ibuprofen) at the same time for pain relief. You should consult with your physician to see if this is an option for you, in addition to discussing some of the general points above.

Zocdoc Answers is for general informational purposes only and is not a substitute for professional medical advice. If you think you may have a medical emergency, call your doctor (in the United States) 911 immediately. Always seek the advice of your doctor before starting or changing treatment. Medical professionals who provide responses to health-related questions are intended third party beneficiaries with certain rights under Zocdoc’s Terms of Service.