I strongly encourage you discuss your concerns with the doctor
prescribing these medications. Without knowing your full medical history, it is not possible to comment on why your doctor has made these medical changes. These details are necessary before I can provide an accurate recommendation.
Hydrochlorothiazide is a diuretic that is commonly used to control blood pressure. It works by preventing your kidneys from resorbing certain electrolytes, which then causes you to urinate additional fluid. 12.5mg daily is a very small dose. Patients often discontinue this medication and restart at a later date without issues. Anxiety
is not a known side effect of this medication, and it is possible the sensation of anxiety you had years ago was unrelated.
Nifedipine is another potent blood pressure medication. Although rare, some people experience leg swelling with this medication, although it would be unlikely for you to experience this now after tolerating it for years. The hand and leg swelling may be because you are no longer on a diuretic. If you have a cardiomyopathy (abnormal heart muscle), the swelling may be a result of congestive heart failure. Again, it is not possible to know this without a thorough history and physical exam, and I encourage you to schedule an appointment with your primary care physician
to discuss this further.