Zocdoc Answers

Medical questions & health advice by board certified doctors

"Will my acyclovir 200mg interact with my 800mg Ibuprofen."


I am a 27 year old male with Herpes simplex virus 2. I am currently taking 2-200mg Acyclovir pills a day. Today I was given a prescription for 800mg Ibuprofen for my migraines. Am I allowed to mix these two pills or should I take one say 2 hours after the other. I'm afraid if I mix the two that one will work and one will not.


Taking multiple medications is a common occurrence, and it is great that you are concerned enough to think about possible interactions. As we age we are more likely to take more and more medications and by the time we are in our 60s and 70s the average number of medications that we take can be as high as seven or eight. With so many medications the likelihood for adverse interactions between drugs increases exponentially.

See a doctor who can help

Find a Primary care-doctors near you

Moreover, doctors are frequently much better at deciding to start a medication than on deciding to stop one and so patients take more and more pills. This is both because of doctors’ inherent bias to prescribe to treat a problem before them and also because the vast majority of scientific studies examine the effect of starting medications with only a handful of studies that examine the effect of stopping medications. To answer your specific question about an interaction between acyclovir and ibuprofen requires a little bit of research. Though, there are classic medication interactions that are taught in medical school, the explosion in new medicines makes it entirely impossible for physicians to know all the potential interactions of the medications they prescribe with the others patients are taking. Here again, there is a real lack of scientific studies to address this problem. Nevertheless, there are some good resources for both patients and doctors. The most common resources are online databases that doctors can use to import patients’ medications into to check for interactions. There are also patient friendly databases that are available online by a number of retail pharmacies. Finally, filling all your medications at the same pharmacy or chain allows for the pharmacist to also check for interactions. In your particular case there are no known clinically significant interactions between ibuprofen and acyclovir and you can take them together without fear. You should talk with your primary care physician for more information. Take care!

Zocdoc Answers is for general informational purposes only and is not a substitute for professional medical advice. If you think you may have a medical emergency, call your doctor (in the United States) 911 immediately. Always seek the advice of your doctor before starting or changing treatment. Medical professionals who provide responses to health-related questions are intended third party beneficiaries with certain rights under Zocdoc’s Terms of Service.