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What causes elevated platelets?

I am a 27 year old female. I’ve been feeling very tired lately, with a slightly depressed mood that has lasted for several weeks. I went to my doctor, where he ordered blood work to be done. When the blood work came back, my doctor called me to tell me that my labs showed Vitamin D deficiency, and that the results from my CBC showed elevated platelets.
Elevated platelets, also called thrombocytosis is a relatively common finding. If your platelet level is just outside the normal range, then it is probably a meaningless finding that can be followed by future blood counts. However, if your platelet levels are much higher than just above the normal range (ie > 600,000), then you should probably have this evaluated. Elevated platelets that are much above the normal range (as above) can be due to a blood disorder called essential thrombocytosis. This is where the cells that make platelets grow out of control. Having platelets are too high from this disorder can cause blood clots or even problems with blood clotting. Elevated platelets can be due to a generalized inflammatory state that occurs when the body is fighting off an infection or recovering from a surgery. Inflammatory disorders such as inflammatory bowel disease or rheumatoid arthritis can cause this. Since you have been feeling tired lately, I would guess that inflammation is a possible cause for your platelets being elevated. If your platelets are greatly elevated, then you need additional testing done. You could schedule an appointment with a hematologist. He or she would know what additional testing would need to be done and would be able to perform a bone marrow biopsy if necessary. If your platelets are only mildly elevated, then I would stick to following your blood counts and symptoms with your primary care physician.
This answer is for general informational purposes only and is not a substitute for professional medical advice.
If you think you may have a medical emergency, call your doctor or (in the United States) 911 immediately. Always seek the advice of your doctor before starting or changing treatment. Medical professionals who provide responses to health-related questions are intended third party beneficiaries with certain rights under ZocDoc’s Terms of Service.

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