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Will Benadryl interfere with the Wellbutrin antidepressant that I take?

I take Benadryl every night to help combat sinus infections that I seem to get on a regular basis. I also take the antidepressant Wellbutrin. I take 150 mg twice a day of Welbutrin SR. I believe the Benadryl I take is 100 mg. I get it over the counter at a discount store. Will these two medications interfere with one another?
Benadryl is an antihistamine medication. It will not directly interact with Wellbutrin. However, Benadryl should not be taken nightly because it has long term effects on sleep architecture, meaning that it will disturb deep sleep. This could adversely affect your depression or anxiety, if these are the reasons that you are taking Wellbutrin. I would highly suggest getting to the bottom of your sinus congestion. This is a problem that is highly solvable with the proper medical oversight and management. Many cases of sinus congestion and nasal allergies are caused by inflammation from particles in the air, such as smoke, dust, mites, and mold. Nasal irrigation with saline solution, using a Nettipot or similar system, can be highly effective. Similarly, there are nonsedating antihistamine medications like loratidine or cetirizine that do not have the same side effects as Benadryl. Finally, nasal steroid sprays can be very effective in keeping symptoms under control. I suggest that you talk to your primary care doctor as soon as possible. They can take a look at your nose and throat and confirm that what is going on is related to your sinuses. If so, they can recommend which are the most appropriate medications for you.
This answer is for general informational purposes only and is not a substitute for professional medical advice.
If you think you may have a medical emergency, call your doctor or (in the United States) 911 immediately. Always seek the advice of your doctor before starting or changing treatment. Medical professionals who provide responses to health-related questions are intended third party beneficiaries with certain rights under ZocDoc’s Terms of Service.

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