HGH or human growth hormone is the most abundant hormone secreted by a hormone production and control center in the brain called the anterior pituitary gland. Growth hormone secretion begins in utero, rises throughout early life, and peaks during puberty. After the pubertal peak, HGH secretion steadily declines by about 50% every 7 years. The steady decline of HGH with aging parallels the overall decrease in body ms that occurs as we grow older. HGH acts by binding to cellular receptors, which, interestingly, are mostly located in the liver. The binding of HGH induces a cascade of cellular signaling that eventually results in the release of other hormones such as IGF-1. The direct and indirect effects of HGH are stimulation of linear growth at the epiphyseal growth plates of long bones, along with some metabolic actions including mobilization of stored fats, stimulation of protein synthesis, opposition of the actions of insulin, and sodium, water, & phosphate retention. There are several inborn disorders of HGH regulation. Oversecretion can result in pituitary giantism. Undersecretion of HGH can lead to growth failure and short stature, so children with this problem are usually administered exogenous HGH.
The best evidence for the negative effects of growth hormone administration come from the French observational SAGhE study. This study demonstrated a small increased risk of death in adults who were treated with recombinant human growth hormone (somatropin) during childhood for certain types of short stature. In the study there were 93 observed deaths in the HGH group versus 70 expected deaths in the general population. The increased mortality in this study was mostly due to bone tumors, cardiovascular events, and bleeding
into the brain. The risk of death was reported to be especially increased when higher than recommended doses of HGH were used. It is for this reason that use of HGH is not recommended unless a doctor
has determined that the benefits are likely to outweigh the risks.
If you are interested in further discussion about the effects hormones have on our body or if you think you may have any signs of hormone deficiency, you need to make an appointment with an endocrinologist
to be fully evaluated and discuss these issues. If you have been taking preparations of GH or other hormones it is important you see a doctor as soon as possible to evaluate whether it has had any negative effect on your health.