ZocdocAnswersWhat chemo drug is better for a 67 year old with cancer?

Question

What chemo drug is better for a 67 year old with cancer?

My Mom is 67 years old and recently diagnosed with colon cancer pT3N1bM0 IIIB. Does she need to go through Chemo? We are concerned since her age and her health condition. Is there any Immunotherapy or that can REPLACE chemo? Or combined with Chemo to reduce the damage caused by Chemo? What medication? If Chemo is absolutely necessary what drug is best choice to my mom? Here is the Pathological diagnosis - pT3N1bM0 IIIB colon cancer mucinous adenocarcinoma at the right corner colon. Middle-to-low differentiated adenocarcinoma. Partial signet-ring cell carcinoma. Attack the full thickness of the surrounding fatty tissue. Cancer acid found in vascular. No cancer seen on the cut. Cancer found around the lymphatic metastasis (3 / 12). Chronic appendicitisand no cancer. Immunohistochemistry CK7 (-) CK20 (+ +) P53 (+++) Ki-67 (80% +) Naked eye detection - a colon with the appendix, intestine 13 cm long, 8 cm perimeter. The small intestine 5 cm long and diameter 2.5 cm. Appendix 6 cm long and diameter of 0.6 cm. At 3 cm from the ileocecal valve can be seen a bulge-shaped mass 3.5 x 2.5 x 1.5. Attack the entire process. Section gray, jelly-like. Mesenteric to 12 lymph nodes, diameter0.4 ~ 0.8 cm.

Answer

First of all I am sorry to hear that your mother has recently been diagnosed with colon cancer. Fortunately, treatment for colon cancer has advanced a lot in recent years, and the prognosis is improving, even in Stage 3 disease like what your mother has where the cancer has moved out of the colon itself and into the lymph nodes. After surgical removal of a colon cancer, when it is found that the cancer is Stage 3, then chemotherapy is absolutely required. This is called adjuvant chemotherapy, and it greatly improves overall survival. The adjuvant chemotherapy regimens that are used in colon cancer treatment have been extensively tested. Although the do cause the typical chemotherapy symptoms, most people tolerate them reasonably well and do well with the treatment. The commonly used drugs are oxaliplatin, fluorouracil, and leucovorin, usually in combination. Although immune type therapies using special antibodies have been designed and studied, these are not at all first line therapy and should not be used first. They have many of their own side effects and are not benign medications either. You should sit down with your mother's cancer doctor who will be able to explain at length the coming treatment course.

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