Medical questions & health advice by board certified doctors

"Are Parkinson?s and Alzheimer?s Disease connected in any way?"

ZocdocAnswersAre Parkinson?s and Alzheimer?s Disease connected in any way?


My aunt has Parkinson?s and my grandmother on the same side has Alzheimer?s. Should I get checked for them regularly? I?m only in my 40?s now, is there an age when they set it in? Are they related as far as my family history is concerned?


First of all, let me say that I am very sorry to hear that your aunt has Parkinson's disease, and your grandmother has Alzheimer's. Both of these neurologic diseases can be very hard to deal/live with for both the patient and their families. As far as I know the short answer to your question is that Alzheimer's and Parkinson's disease are not directly related. That does not mean that you shouldn't talk to a neurologist and get evaluated if you have concerns. Alzheimer's is an incurable neuro-degenerative disease first discovered by (and named after) the German pathologist Alois Alzhemer in 1906. It is characterized pathologically by amyloid plaques and neurofibrillary tangles as well as a loss of neurons within the cerebral cortex. There is a (rare) form of Alzheimer's that is familial 50% of the time called early-onset Alzheimer dementia in which it is diagnosed earlier than the age of 65 (usually diagnosed after this). Some theories on Alzheimer's think that there is an underproduction of a neurotransmitter acetycholine. Parkinson's disease on the other hand is a degenerative disorder which results from death of dopaminergic (different neurotransmitter) cells within the substantia nigra of the midbrain. Pathologic examination shows something called Lewy bodies. Thus they are two separate entities altogether. I would recommend making an appointment with a neurologist to discuss your concerns. I hope this information is helpful.

Zocdoc Answers is for general informational purposes only and is not a substitute for professional medical advice. If you think you may have a medical emergency, call your doctor (in the United States) 911 immediately. Always seek the advice of your doctor before starting or changing treatment. Medical professionals who provide responses to health-related questions are intended third party beneficiaries with certain rights under Zocdoc’s Terms of Service.