{"id":19205,"date":"2021-08-16T20:10:46","date_gmt":"2021-08-17T01:10:46","guid":{"rendered":"https:\/\/thepapergown.zocdoc.com\/?p=19205"},"modified":"2023-03-20T13:44:48","modified_gmt":"2023-03-20T18:44:48","slug":"5-people-on-taking-ketamine-for-depression","status":"publish","type":"post","link":"https:\/\/www.zocdoc.com\/blog\/guides\/5-people-on-taking-ketamine-for-depression\/","title":{"rendered":"5 People On Taking Ketamine For Depression"},"content":{"rendered":"

About 17 million Americans<\/a> are estimated to have depression, a mood disorder defined by<\/a> feelings of sadness and hopelessness, and a loss of interest in normal activities. (Prototypical depression is technically called major depression, and it’s one of six different depression disorders.) There are well-established treatments for depression, including psychotherapy and various antidepressants. But for people whose depression is treatment-resistant or especially severe, doctors sometimes pursue less conventional solutions. Enter: ketamine.<\/span><\/p>\n

Originally developed in the 1960s as a surgical anesthetic, ketamine later became a popular party drug thanks to its hallucinogenic and euphoric effects. More recently, doctors have been prescribing ketamine infusions as an off-label<\/a> treatment for PTSD, chronic pain and, most notably, depression. Ketamine appears to work well, even when other depression treatments don’t. One study found that up to 85% <\/a>of people who try ketamine for depression say it’s effective. It also works really fast, alleviating symptoms within days<\/a> or sometimes hours. Doctors typically don’t administer ketamine themselves. Instead, patients go to freestanding ketamine clinics<\/a> periodically \u2014 anywhere from every week to every few months, depending on the severity of their condition.<\/p>\n

There’s some evidence to suggest ketamine alleviates depression by increasing the available supply of serotonin in the brain. Another theory<\/a> says it\u00a0helps recreate neural pathways damaged by depression and stress.<\/p>\n

What’s it actually like to take ketamine for depression? We talked to five people who’ve done it. Here’s what they had to say.<\/p>\n

\n

“After two treatments, I noticed I was laughing again.”<\/h3>\n

Alice, 40, Virginia<\/em><\/p>\n

Alice started seeing a psychotherapist at five years old for low-grade depression and generalized anxiety. But her life-long mental health struggles worsened in her<\/span> mid-20s, when she began experiencing suicidal ideation. <\/span><\/p>\n

Then, in 2016, she endured her worst-ever depressive episode. \u201cI couldn\u2019t stand the reality of being alive,\u201d she says. <\/span>Around the same time, Alice, who’s a journalist, learned about ketamine while writing a story about the use of electroconvulsive therapy (ECT) for treatment-resistant depression. While the potential side effects of ECT were too worrisome, ketamine piqued her interest.\u00a0<\/span><\/p>\n

Alice reached out to a doctor, whom she also found while doing research for her story, and they prescribed ketamine.<\/span> She did seven infusions total \u2014 two per week for three weeks, plus one booster session a few months later. At first, the process gave her anxiety. “B<\/span>ut after two treatments, I noticed I was laughing again,” she says<\/span>. Alice received her final infusion in October 2018. She’s stable today, she says, but she still takes an antidepressant and sees a therapist weekly.<\/span><\/p>\n

\n

\u201cThe ketamine is carrying all the weight here.\u201d<\/h3>\n

Trevor, 47, Calgary<\/em><\/p>\n

For Trevor, depression and chronic pain have always gone hand in hand, each exacerbating the other. Several years ago, he was struggling to find medication that worked to boost his mood. His psychiatrist recommended ketamine infusions, but said actually finding them might take a while. Ketamine was an approved treatment for some conditions in his Canadian province, but depression wasn’t one of them.<\/span><\/p>\n

Around the same time, a pain management specialist diagnosed Trevor with complex regional pain syndrome<\/a>, a form of chronic pain in the arms and legs that typically emerges after an injury. That doctor\u2019s proposed treatment? Ketamine. The next day, Trevor went to a pain clinic for his first infusion. His pain improved drastically \u2014 and so did his depression. He began weekly treatment.\u00a0<\/span><\/p>\n

\u201cI was experiencing major relief for my pain, but what really amazed me was that on my treatment mornings, my kids were so excited to come have breakfast with me,\u201d Trevor says. \u201cThey were starting to get their dad back.\u201d<\/span><\/p>\n

These days, Trevor feels better than he ever expected to. He still gets ketamine infusions about every two months. He also takes a low dose of an antidepressant, which he plans to stop taking soon. \u201cMy family doctor said it\u2019s such a low dose, it\u2019s arguably not doing anything,\u201d he says. \u201cThe ketamine is carrying all the weight here.\u201d<\/span><\/p>\n

\n

 <\/p>\n

“It was like I finally saw a bit of light at the end of a dark tunnel.”<\/h3>\n

Sam, 35, Toronto<\/em><\/p>\n

Sam\u2019s depression first hit around age 14, when she was forced to give up competitive figure skating. She developed an eating disorder and anxiety around the same time. After several years of ups and downs, her therapist and dietitian encouraged her to see a psychiatrist.\u00a0<\/span>Though Sam was eager to feel better, none of the antidepressants she tried worked. In fact, she had a bad reaction to nearly all of them. \u201cIt was a really sad way to live,\u201d Sam says.<\/span><\/p>\n

That\u2019s when her primary care doctor, who was treating her eating disorder, mentioned ketamine. Against her parents\u2019 wishes, Sam decided to try it. Her doctor found a ketamine clinic, and they set her up for three back-to-back infusions starting the following week.\u00a0<\/span><\/p>\n

That was September 2017. A week after her first infusion, “It was like I finally saw a bit of light at the end of a dark tunnel,” she says. She ended up going to in-patient treatment for her eating disorder shortly after starting ketamine. There, as her mood started to drop without it, she began getting infusions again. Between those treatments and ED treatment, which involved psychotherapy, Sam saw major improvements in her mental health. For a few years, she got ketamine infusions every month throughout the US, depending on where she was living.<\/span><\/p>\n

Now that she lives in Canada, where ketamine isn\u2019t as readily available, she plans to travel to the US for maintenance doses when she can \u2014 ideally, once a month.\u00a0 She\u2019s also finally found a depression medication she can tolerate, which helps her get by between infusions.\u00a0<\/span><\/p>\n

\n

\u201cIt showed me it\u2019s possible to find enjoyment and pleasure in life again.”<\/h3>\n

Jack, 38, Tennessee\u00a0<\/em><\/p>\n

At 22, Jack was hospitalized for five days after having a nervous breakdown at work. His psychiatrist prescribed antidepressants, anti-anxiety medications and antipsychotics. Still, over the next few years, Jack checked himself back into the hospital multiple times. He also saw several different psychotherapists for his depression and shuffled between ineffective medications.\u00a0<\/span><\/p>\n

About a decade after his first hospitalization, Jack\u2019s father died and he slipped into another depressive episode. He began researching other treatment options and learned about ketamine.<\/span><\/p>\n

He found a local ketamine clinic and did six infusions in the span of two weeks. While he noticed a general attitude shift almost immediately, he says the real effects started the morning after his sixth treatment. Everything felt less nerve-wracking and depressing. \u201cI hadn\u2019t felt like that in over a decade,\u201d he says.<\/span><\/p>\n

Jack still struggles with depression and anxiety, for which he currently takes psychiatric medications. He hasn’t had a ketamine infusion in over a year because the treatment is too expensive. But even knowing ketamine exists as an option, he says, gives him hope. He’d get more infusions if he could afford them: \u201cIt showed me it\u2019s possible to find enjoyment and pleasure in life again.”<\/span><\/p>\n

\n

\u201cIt\u2019s a night-and-day change.\u201d<\/h3>\n

Kendall, 32, Virginia\u00a0<\/em><\/p>\n

Kendall had been taking antidepressants for 15 years when her psychiatrist told her about ketamine. While she’d managed to overcome an eating disorder, her depression persisted through every antidepressant she tried \u2014 and she’d tried pretty much everything out there. At one point, she recalls asking her psychiatrist, \u201cHow long do you expect me to stick around for a life that\u2019s not worth living?\u201d\u00a0<\/span><\/p>\n

In 2019, she and her doctor found an ER physician who\u2019d opened a ketamine clinic. She noticed a major change in her mood hours after her first infusion. \u201cI\u2019m at the point where I\u2019ve had two years of regular infusions and I don\u2019t really see a dip in my mood anymore,\u201d she says.\u00a0<\/span><\/p>\n

Currently, Kendall gets an infusion every five weeks. She also takes an antidepressant, at a much lower dose than she did before ketamine, and continues to see the therapist she\u2019s been seeing for the last five years. When depression creeps up \u2014 which it sometimes does \u2014 she’s able to rationalize her way out of low moods instead of spiraling further. \u201cWith ketamine, I can use the tools I\u2019ve learned to help alleviate my depression,\u201d she says. \u201cIt\u2019s a night-and-day change.\u201d<\/span><\/p>\n

\n

Ready to book a therapist’s appointment? Visit Zocdoc.<\/span><\/a><\/span><\/h1>\n","protected":false},"excerpt":{"rendered":"

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