About Dr. Manish Sagar
Dr. Manish Sagar is a Professor of Medicine at the Chobanian and Avedisian School of Medicine. He earned his Doctor of Medicine from Johns Hopkins University, completed internship and residency in Internal Medicine at The Johns Hopkins Hospital, and pursued a fellowship in Infectious Diseases at the University of Washington.
His laboratory focuses on human immunodeficiency virus type 1 (HIV-1) mucosal transmission and antibodies. One focus is understanding the biological mechanisms underlying the selection during HIV-1 transmission. Although chronically infected subjects harbor extensive viral variants, only a limited number are acquired by newly infected partners. Genotypic comparison of viruses in the newly infected subject versus the transmitting partner suggests the genetic bottleneck during transmission is not random. Laboratory studies explore the hypothesis that specific variants with properties conferring fitness for transmission are selected.
Another focus is deciphering correlates of immune protection. Even though infants are exposed to infected breast milk, only about 30% acquire HIV-1 from their infected mother without antiretroviral protection. The lab hypothesizes maternally acquired antibodies in the infant prevent HIV-1 acquisition through neutralization or antibody-dependent cellular cytotoxicity against variants in maternal breast milk. Defining this immune correlate of protection has important implications for HIV-1 vaccine design. Their work examines HIV-1 envelope and host antibody evolution and their impact on disease pathogenesis.
Dr. Sagar has served on numerous committees, including NIH study sections and the Doris Duke Charitable Foundation Early Career Development Award Review Committee. He is an active member of the Infectious Diseases Society of America (IDSA).
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Office location
Education and background
Practice names
Board certifications
- American Board of Internal Medicine
- Infectious Disease (American Board of Internal Medicine)
Education and training
- Medical School - Johns Hopkins University, Doctor of Medicine
- The Johns Hopkins Hospital, Residency in Internal Medicine
- The Johns Hopkins Hospital, Internship in Internal Medicine
- University of Washington, Fellowship in Infectious Diseases
- Columbia University (Bachelor's)
Professional memberships
- Infectious Diseases Society of America
Awards and publications
- Sagar M, Laeyendecker O, Lee S, Gamiel J, Wawer MJ, Gray RH, Serwadda D, Sewankambo NK, Shepherd JC, Toma J, Huang W, Quinn TC. 2009. Selection of HIV variants with signature genotypic characteristics during heterosexual transmission. J Infec Dis. 199: 580-9. PMID: 19143562
- Etemad B, Fellows A, Kamat A, Kwambana B, Sagar M. 2009. HIV-1 V1-V5 envelope variants from the chronic phase of infection use CCR5 and fuse more efficiently than those from early after infection J Virol. 83(19):9694-708. PMID: 19625411
- Sagar M, Akiyama H, Etemad B, Ramirez N, Freitas I, Gummuluru S. 2012. Transmembrane Domain Membrane Proximal External Region but not Surface Unit Directed Broadly Neutralizing HIV-1 Antibodies can Restrict Dendritic Cell Mediated HIV-1 Trans Infection. J Infect Dis. 205(8):1248-57. PMID: 22396600
- Chatziandreou N, Belen Arauz A, Freitas I, Nyein PH, Fenton G, Mehta SH,. Kirk GD Sagar M. 2012. Sensitivity changes over the course of infection increases the likelihood of resistance against fusion but not CCR5 receptor blockers. AIDS Res Hum Retroviruses 28(12):1584-93. PMID: 22650962
- Lin N, Becerril, C, Giguel F, Novitsky V, Moyo S, Makhema J, Essex M, Lockman S, Kuritzkes D, Sagar M. 2012. Env Sequence Determinants in CXCR4-using Human Immunodeficiency Virus Type-1 Subtype C. Virol. 433(2):296-307. PMID: 22954962
Languages spoken
- English
- Hindi
Provider's gender
Male
NPI number
1811954050
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What practice does Dr. Manish Sagar work with?
Dr. Manish Sagar works with Boston Medical Center Travel Clinic.
Where is Dr. Manish Sagar's office located?
Dr. Manish Sagar's office is located at 725 Albany St, Boston, MA 02118.
Which board certifications does Dr. Manish Sagar have?
Dr. Manish Sagar is certified by American Board of Internal Medicine and Infectious Disease (American Board of Internal Medicine).
What languages does Dr. Manish Sagar speak?
Dr. Manish Sagar speaks English and Hindi.